Description

Methyl (2S)-2-Methylazetidine-2-Carboxylate Hcl is a high-purity chiral building block and a key intermediate in advanced organic synthesis. This compound is valued for its rigid azetidine ring structure, which is increasingly important in the design of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly in medicinal chemistry for creating constrained analogs and peptidomimetics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational restraint into drug-like molecules.
• Peptidomimetic Development: Serves as a proline or other amino acid analog for creating novel peptides with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex chiral centers.
• Agrochemical Research: Potential intermediate in the development of new herbicides or fungicides with specific chiral activity.
• Ligand and Catalyst Design: Useful for constructing novel chiral ligands for metal-catalyzed reactions or organocatalysts.

Basic Information

Product Name	Methyl (2S)-2-Methylazetidine-2-Carboxylate Hydrochloride
CAS No.	1391080-13-9
Molecular Formula	C6H12ClNO2
Molecular Weight	165.62 g/mol
Synonyms	(2S)-2-Methylazetidine-2-carboxylic acid methyl ester hydrochloride; Methyl L-2-methylazetidine-2-carboxylate hydrochloride; (S)-Methyl 2-methylazetidine-2-carboxylate HCl; 2-Azetidinecarboxylic acid, 2-methyl-, methyl ester, hydrochloride, (2S)-; L-2-Methylazetidine-2-carboxylic acid methyl ester HCl; Az-OMe.HCl (common abbreviation)
EINECS	Contact for details

Quality Control

Our Methyl (2S)-2-Methylazetidine-2-Carboxylate Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.