Description

[[n-Cyclopropyl-(3-Fluoro-4-Methoxyphenyl)Amino]Methylene]-Propanedioic Acid Diethyl Ester is a high-value, advanced pharmaceutical intermediate with a complex molecular architecture designed for targeted synthesis. This compound matters because it serves as a critical building block in the development of novel active pharmaceutical ingredients (APIs), enabling precise chemical modifications. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring sophisticated heterocyclic and fluorinated chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or oncological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a standard or reference material for scaling up and optimizing synthetic routes in pilot plants and commercial manufacturing.
• Fluorinated Compound Synthesis: Exploits the 3-fluoro-4-methoxyphenyl moiety for creating compounds with enhanced metabolic stability, bioavailability, and membrane permeability.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry in custom synthesis and development projects.

Basic Information

Product Name	[[n-Cyclopropyl-(3-Fluoro-4-Methoxyphenyl)Amino]Methylene]-Propanedioic Acid Diethyl Ester
CAS No.	1391054-38-8
Molecular Formula	C18H22FNO5
Molecular Weight	351.37 g/mol
Synonyms	Diethyl 2-[[Cyclopropyl(3-fluoro-4-methoxyphenyl)amino]methylene]propanedioate; Propanedioic acid, [[[cyclopropyl(3-fluoro-4-methoxyphenyl)amino]methylene]]-, diethyl ester; (2E)-2-{[Cyclopropyl(3-fluoro-4-methoxyphenyl)amino]methylene}malonic acid diethyl ester; (E)-Diethyl 2-(cyclopropyl(3-fluoro-4-methoxyphenyl)amino)methylene)malonate; 1391054-38-8; FC-1388 (Potential R&D Code); CPFMPA-Malonate Ester
EINECS	Contact for details

Quality Control

Our [[n-Cyclopropyl-(3-Fluoro-4-Methoxyphenyl)Amino]Methylene]-Propanedioic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.