Description

(E)-1-(4-Hydroxy-Phenyl)-3-(2,4,6-Trimethoxy-Phenyl)-Propenone is a high-purity, synthetic chalcone derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a versatile and critical building block for developing novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new molecular entities with targeted biological activities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting inflammatory and metabolic pathways.
• Chemical Biology Probe: Used in research to study enzyme inhibition, protein-ligand interactions, and cellular signaling mechanisms due to its chalcone scaffold.
• Agrochemical Development: Serves as a core structure for creating new plant growth regulators or crop protection agents with enhanced efficacy.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing advanced polymers with specific optical or electronic properties.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses, including Michael additions and cyclization reactions, to construct diverse heterocyclic compounds.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling in related pharmaceutical processes.

Basic Information

Product Name	(E)-1-(4-Hydroxy-Phenyl)-3-(2,4,6-Trimethoxy-Phenyl)-Propenone
CAS No.	1389310-69-3
Molecular Formula	C18H18O5
Molecular Weight	314.33 g/mol
Synonyms	(E)-1-(4-Hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one; 2-Propen-1-one, 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)-, (E)-; 4'-Hydroxy-2',4',6'-trimethoxychalcone; NSC 407296; Chalcone derivative 1389310-69-3; Light-sensitive chalcone; Trimethoxychalcone derivative
EINECS	Contact for details

Quality Control

Our (E)-1-(4-Hydroxy-Phenyl)-3-(2,4,6-Trimethoxy-Phenyl)-Propenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.