Description

(4Alpha,6Alpha)-1-Boc-6-Hydroxy-1-Azaspiro[3.3]Heptane is a high-purity, protected heterocyclic amine building block of significant interest in advanced pharmaceutical research and development. This compound matters because it provides a versatile, chiral scaffold for constructing complex molecules, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates. Pharmaceutical R&D chemists and process development scientists need this key intermediate to explore new therapeutic modalities, including protease inhibitors and other small-molecule drugs targeting challenging disease pathways.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Protease Inhibitor Scaffold: Used in the research and development of potential inhibitors for various protease enzymes.
• Medicinal Chemistry: Serves as a versatile spirocyclic core structure for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in route scouting and scale-up development for the commercial manufacturing of complex therapeutic molecules.
• Chemical Biology: Utilized as a molecular probe or a tagged ligand in biochemical assays and target identification studies.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(4Alpha,6Alpha)-1-Boc-6-Hydroxy-1-Azaspiro[3.3]Heptane
CAS No.	1389264-27-0
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	1-Boc-6-Hydroxy-1-azaspiro[3.3]heptane; tert-Butyl (4α,6α)-6-hydroxy-1-azaspiro[3.3]heptane-1-carboxylate; 1-Azaspiro[3.3]heptane-6-ol, 1-(1,1-dimethylethoxy)carbonyl-, (4α,6α)-; (4α,6α)-1-(tert-Butoxycarbonyl)-6-hydroxy-1-azaspiro[3.3]heptane; 1-N-Boc-6-hydroxy-1-azaspiro[3.3]heptane; Boc-protected azaspiroheptanol; (4α,6α)-6-Hydroxy-1-azaspiro[3.3]heptane-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (4Alpha,6Alpha)-1-Boc-6-Hydroxy-1-Azaspiro[3.3]Heptane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.