Description

3-Bromo-5-Fluoroimidazo[1,2-A]Pyridine is a high-value, multi-functional heterocyclic building block of significant interest in modern synthetic chemistry. Its core value lies in its unique fused-ring structure, which incorporates both bromine and fluorine atoms, making it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its specific reactivity profile enables critical carbon-carbon and carbon-heteroatom bond-forming reactions essential for drug discovery and material science programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates targeting a range of therapeutic areas, including CNS disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity often associated with halogenated imidazopyridine scaffolds.
• Material Science Precursor: Serves as a starting material for creating specialized ligands, organic semiconductors, or photoactive compounds for advanced material applications.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to introduce diverse functional groups.
• Medicinal Chemistry SAR Studies: Utilized to explore structure-activity relationships (SAR) by systematically modifying the core imidazopyridine structure.
• Chemical Biology Probes: Can be functionalized to create molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	3-Bromo-5-Fluoroimidazo[1,2-A]Pyridine
CAS No.	1388711-44-1
Molecular Formula	C7H4BrFN2
Molecular Weight	215.03 g/mol
Synonyms	3-Bromo-5-fluoroimidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 3-bromo-5-fluoro-; 5-Fluoro-3-bromoimidazo[1,2-a]pyridine; 1388711-44-1; 3-Bromo-5-fluoro-imidazo[1,2-a]pyridine; AI3-63872; BRN 12506673; ZINC000257019911
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoroimidazo[1,2-A]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We are committed to meeting the stringent requirements of research and cGMP environments, with specifications available for various grades including standard and high-purity research grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.