Description

2-Azaspiro[3.3]heptan-6-ol, 6-(trifluoromethyl)-, hydrochloride (1:1) is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold and a trifluoromethyl group, which are critical motifs in modern drug discovery. This compound is essential for medicinal chemistry research and development, offering significant potential to enhance the pharmacokinetic and metabolic properties of novel therapeutic candidates. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of innovative small-molecule drugs targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to improve drug-like properties such as metabolic stability and membrane permeability.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• CNS Drug Discovery: The spirocyclic structure is valuable for creating compounds designed to cross the blood-brain barrier for treating neurological conditions.
• Agrochemical Research: Potential intermediate in the development of new generation pesticides and herbicides, leveraging the stability imparted by the fluorine atoms.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	2-Azaspiro[3.3]heptan-6-ol, 6-(trifluoromethyl)-, hydrochloride (1:1)
CAS No.	1384431-10-0
Molecular Formula	C7H11ClF3NO
Molecular Weight	217.62 g/mol
Synonyms	6-(Trifluoromethyl)-2-azaspiro[3.3]heptan-6-ol hydrochloride; 6-(Trifluoromethyl)-2-azaspiro[3.3]heptan-6-ol HCl; 2-Azaspiro[3.3]heptan-6-ol, 6-(trifluoromethyl)-, hydrochloride; 6-Hydroxy-6-(trifluoromethyl)-2-azaspiro[3.3]heptane hydrochloride; 6-Trifluoromethyl-2-azaspiro[3.3]heptan-6-ol hydrochloride; 1384431-10-0; 2-Aza-6-(trifluoromethyl)spiro[3.3]heptan-6-ol hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Azaspiro[3.3]heptan-6-ol, 6-(trifluoromethyl)-, hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development and commercial projects with material produced under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.