Description

(2R)-2-(2-Chloro-4-Fluoro-Phenyl)Pyrrolidine Hcl is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its defined stereochemistry and functionalized pyrrolidine core, which is a privileged scaffold in medicinal chemistry for developing bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries engaged in the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorders.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry influences biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Research: A valuable reference standard and building block in academic and industrial R&D for exploring new chemical entities.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of fine chemicals.

Basic Information

Product Name	(2R)-2-(2-Chloro-4-Fluoro-Phenyl)Pyrrolidine Hydrochloride
CAS No.	1381929-04-9
Molecular Formula	C10H12ClFN•HCl
Molecular Weight	234.12 g/mol (Free base: 197.66 g/mol)
Synonyms	(R)-2-(2-Chloro-4-fluorophenyl)pyrrolidine hydrochloride; (2R)-2-(2-Chloro-4-fluorophenyl)pyrrolidine HCl; (R)-2-(2-Chloro-4-fluoro-phenyl)-pyrrolidine hydrochloride; 1381929-04-9; (R)-2-(2-Chloro-4-fluorophenyl)pyrrolidine monohydrochloride; (2R)-2-(2-Chloro-4-fluoro-phenyl)-pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-2-(2-Chloro-4-Fluoro-Phenyl)Pyrrolidine Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.