Description

2,8-Diazaspiro[4.5]Decan-3-One, 2-Ethyl- CAS NO 1380386-77-5 is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic diazepanone class of heterocyclic compounds. This compound is of significant commercial interest due to its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates targeting neurological receptors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing libraries of novel bioactive molecules in high-throughput screening.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for potential new chemical entities (NCEs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials.
• Academic Research: Employed in university and institutional labs for studying spirocyclic compound reactivity and pharmacology.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or labeled compounds for biochemical assays due to its functionalizable nitrogen atoms.

Basic Information

Product Name	2,8-Diazaspiro[4.5]Decan-3-One, 2-Ethyl-
CAS No.	1380386-77-5
Molecular Formula	C10H18N2O
Molecular Weight	182.26 g/mol
Synonyms	2-Ethyl-2,8-diazaspiro[4.5]decan-3-one; 2-Ethyl-3-oxo-2,8-diazaspiro[4.5]decane; 2-Ethyl-2,8-diazaspiro[4.5]decan-3-one; 2-Ethyl-2,8-diazaspiro[4.5]decan-3-one; 2-Ethyl-3-oxo-2,8-diazaspiro[4.5]decane; 2-Ethyl-2,8-diazaspiro[4.5]decan-3-one hydrochloride (salt form); Spiro[diazepanone] intermediate; Ethyl-diazaspirodecanone
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[4.5]Decan-3-One, 2-Ethyl- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.