Description

3-Azido-D-Alanine Hcl CAS NO 1379690-01-3 is a non-natural, azide-functionalized amino acid derivative used as a key building block in chemical biology and pharmaceutical research. Its core value lies in the bio-orthogonal reactivity of the azide group, enabling selective conjugation via click chemistry for applications like bioconjugation, peptide modification, and probe development. This high-purity intermediate is essential for researchers and manufacturers in the fields of peptide synthesis, drug discovery, proteomics, and the development of antibody-drug conjugates (ADCs).

Application

• Peptide Synthesis & Modification: Incorporation of azide handles into peptide sequences for subsequent labeling or conjugation via click chemistry (e.g., CuAAC, SPAAC).
• Bioconjugation & ADC Development: A critical linker component for attaching cytotoxic payloads or fluorescent tags to antibodies, proteins, or other biomolecules.
• Chemical Biology Probes: Synthesis of activity-based probes (ABPs) or affinity-based probes for studying enzyme function and protein interactions.
• Material Science & Surface Functionalization: Modification of polymers, nanoparticles, or surfaces with bio-active azide groups for creating smart materials or biosensors.
• Metabolic Labeling: Potential use as a metabolic precursor for incorporating azide tags into newly synthesized proteins or other cellular components.
• Pharmaceutical Intermediate: Serves as a specialized chiral building block in the synthesis of novel therapeutic candidates and bioactive compounds.

Basic Information

Product Name	3-Azido-D-Alanine Hcl
CAS No.	1379690-01-3
Molecular Formula	C3H7N5O2 • HCl
Molecular Weight	197.59 g/mol
Synonyms	D-3-Azidoalanine hydrochloride; (R)-2-Amino-3-azidopropanoic acid hydrochloride; Azido-D-alanine HCl; 3-Azido-D-alanine hydrochloride; D-β-Azidoalanine hydrochloride; (R)-3-Azidoalanine HCl; 3-Azido-(R)-alanine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Azido-D-Alanine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.