Description

Trimethylsilyl 3,3,3-Trifluoropropionate is a specialized organosilicon reagent featuring a trifluoropropionate ester group protected by a trimethylsilyl moiety. This compound is valued for its role as a versatile synthetic building block, particularly in introducing the biologically relevant trifluoromethyl group into target molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients. Its unique structure makes it a key intermediate in advanced organic synthesis and fluorination chemistry.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing trifluoromethyl groups, which enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Fluorinated Material Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and advanced materials with unique surface properties.
• Organic Synthesis Reagent: Employed in nucleophilic acyl substitution and transesterification reactions under mild conditions, facilitated by the silyl group.
• Proteomics & Biochemistry: Potential use as a derivatization agent for mass spectrometry to improve the detection of carboxylic acid-containing metabolites.
• Liquid Crystal & OLED Material Research: Acts as an intermediate for creating fluorinated components used in electronic display technologies.

Basic Information

Product Name	Trimethylsilyl 3,3,3-Trifluoropropionate
CAS No.	1379343-44-8
Molecular Formula	C8H13F3O2Si
Molecular Weight	214.27 g/mol
Synonyms	3,3,3-Trifluoropropionic Acid Trimethylsilyl Ester; Trimethylsilyl 3,3,3-Trifluoropropanoate; TMS 3,3,3-Trifluoropropionate; (Trimethylsilyl) 3,3,3-Trifluoropropionate; Propanoic Acid, 3,3,3-Trifluoro-, Trimethylsilyl Ester; TMS-TFP; Silicon, Trimethyl(3,3,3-Trifluoro-1-Oxopropoxy)-
EINECS	Contact for details

Quality Control

Our Trimethylsilyl 3,3,3-Trifluoropropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet your specific R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.