Description

4-Bromo-2-Chloro-3-Nitropyridine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and other advanced materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromo and chloro substituents.
• Nucleophilic Aromatic Substitution: The nitro and halogen groups make it highly reactive for selective substitution, enabling diverse molecular architectures.
• Chemical Biology Probes: Used to develop labeled compounds and molecular probes for biochemical and pharmacological research.

Basic Information

Product Name	4-Bromo-2-Chloro-3-Nitropyridine
CAS No.	1379309-70-2
Molecular Formula	C5H2BrClN2O2
Molecular Weight	237.44 g/mol
Synonyms	2-Chloro-4-bromo-3-nitropyridine; 3-Nitro-2-chloro-4-bromopyridine; 4-Bromo-2-chloro-3-nitro-pyridine; Pyridine, 4-bromo-2-chloro-3-nitro-; 1379309-70-2; 2-Chloro-4-bromo-3-nitro-pyridine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-3-Nitropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.