Description

Siponimod is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator, identified by the CAS registry number 1378888-43-7. This small molecule pharmaceutical agent is of critical importance for its targeted mechanism of action in modulating immune cell trafficking. It is primarily required by pharmaceutical research and development organizations, as well as contract manufacturing organizations (CMOs), engaged in the development of advanced therapies for autoimmune and neurological conditions.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key therapeutic component in finished dosage forms.
• Reference Standard: Serves as a high-purity benchmark for analytical method development, validation, and quality control testing in regulatory submissions.
• Clinical Research Material: Used in the formulation of investigational medicinal products (IMPs) for Phase I-III clinical trials.
• Process Development & Scale-Up: Essential raw material for optimizing synthetic routes and establishing robust manufacturing processes.
• Bioavailability & Pharmacokinetic Studies: Utilized in preclinical and clinical research to study absorption, distribution, metabolism, and excretion (ADME) profiles.
• Impurity Synthesis & Characterization: Acts as a starting material or reference for the synthesis and identification of potential degradants and process-related impurities.

Basic Information

Product Name	Siponimod
CAS No.	1378888-43-7
Molecular Formula	C29H35FN2O3
Molecular Weight	478.60 g/mol
Synonyms	BAF312; 1-{4-[(1E)-1-({[4-cyclohexyl-3-(trifluoromethyl)phenyl]amino}carbonyl)ethenyl]-2-ethylbenzyl}azetidine-3-carboxylic acid; (E)-1-(4-(1-((4-Cyclohexyl-3-(trifluoromethyl)phenyl)carbamoyl)vinyl)-2-ethylbenzyl)azetidine-3-carboxylic acid; Mayzent (brand name)
EINECS	Contact for details

Quality Control

Our Siponimod is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods, purity assessment by HPLC, and stringent control of residual solvents and impurities in accordance with ICH guidelines. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F), in a dry environment. The container should be kept in a well-ventilated area and handled according to standard laboratory safety protocols for pharmaceutical intermediates.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.10%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.