Description

tert-Butyl 1-Oxa-8-Azaspiro[4.5]Dec-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with potential biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within therapeutic areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting the central nervous system (CNS) or other specialized therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex target molecules during process development and scale-up.
• Chemical Biology Probes: Employed in the design and synthesis of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	tert-Butyl 1-Oxa-8-Azaspiro[4.5]Dec-3-Ylcarbamate
CAS No.	1377187-33-1
Molecular Formula	C13H24N2O3
Molecular Weight	256.34 g/mol
Synonyms	1-Oxa-8-azaspiro[4.5]dec-3-yl-carbamic acid tert-butyl ester; tert-Butyl 1-oxa-8-azaspiro[4.5]decane-3-carboxylate; 1-Oxa-8-azaspiro[4.5]dec-3-yl-carbamic acid 1,1-dimethylethyl ester; 8-Azaspiro[4.5]dec-3-yl, 1-oxa-, tert-butyl carbamate; tert-Butyl 1-oxa-8-azaspiro[4.5]dec-3-ylcarbamate; BOC-1-Oxa-8-Azaspiro[4.5]Dec-3-Ylamine (common precursor name); Spirocyclic carbamate intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Oxa-8-Azaspiro[4.5]Dec-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.