Description

2-Difluoromethoxy-Isonicotinic Acid Methyl Ester is a high-purity fluorinated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique difluoromethoxy group, which is strategically incorporated to modulate the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients requiring enhanced bioavailability and stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in developing kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the difluoromethoxy moiety can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for creating specialized fluorinated ligands, catalysts, or monomers for advanced polymers with specific thermal or chemical resistance.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes and labeled compounds for studying biological mechanisms and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards for client-specific molecules.

Basic Information

Product Name	2-Difluoromethoxy-Isonicotinic Acid Methyl Ester
CAS No.	1375098-09-1
Molecular Formula	C9H7F2NO3
Molecular Weight	215.15 g/mol
Synonyms	Methyl 2-(difluoromethoxy)isonicotinate; 2-(Difluoromethoxy)isonicotinic Acid Methyl Ester; Isonicotinic Acid, 2-(difluoromethoxy)-, Methyl Ester; 4-Pyridinecarboxylic Acid, 2-(difluoromethoxy)-, Methyl Ester; Methyl 2-(Difluoromethoxy)-4-pyridinecarboxylate; 1375098-09-1; DFM-isonicotinate Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of 2-Difluoromethoxy-Isonicotinic Acid Methyl Ester is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality commitment supports development from research to commercial scale, adhering to relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.