Description

(E)-Ethyl 3-(4-(Difluoromethoxy)Phenyl)Acrylate is a high-purity, synthetic organic intermediate characterized by its acrylate ester functionality and difluoromethoxy-substituted aromatic ring. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling the introduction of specific fluorinated motifs into target molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Development: Serves as a building block for fluorinated components in electronic display materials, contributing to improved performance and stability.
• Organic Synthesis & Chemical Research: Employed in academic and industrial R&D for constructing complex molecules, studying structure-activity relationships (SAR), and developing new synthetic methodologies.
• Fluorinated Polymer Monomer: Investigated for use in the creation of specialty polymers with unique surface properties, chemical resistance, and optical characteristics.

Basic Information

Product Name	(E)-Ethyl 3-(4-(Difluoromethoxy)Phenyl)Acrylate
CAS No.	1374856-34-4
Molecular Formula	C₁₂H₁₂F₂O₃
Molecular Weight	242.22 g/mol
Synonyms	Ethyl (E)-3-[4-(Difluoromethoxy)phenyl]acrylate; (E)-Ethyl 3-(4-(Difluoromethoxyphenyl))propenoate; Ethyl (E)-3-(4-(Difluoromethoxy)phenyl)-2-propenoate; 2-Propenoic acid, 3-[4-(difluoromethoxy)phenyl]-, ethyl ester, (E)-; 4-(Difluoromethoxy)cinnamic acid ethyl ester; DFMPA ethyl ester; EDFPA. Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 3-(4-(Difluoromethoxy)Phenyl)Acrylate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0% (Typical 98.0-99.5%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.