Description

1-Boc-1-Azaspiro[3.3]Heptane-6-Carboxylic Acid is a high-value, protected amino acid derivative featuring a rigid spirocyclic scaffold, making it a critical building block for advanced pharmaceutical research and development. Its primary value lies in enabling the synthesis of novel, conformationally constrained molecules with potential for enhanced biological activity and metabolic stability. This compound is essential for medicinal chemists and process development scientists working in drug discovery, particularly for targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas requiring complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry: Used to introduce the constrained 1-azaspiro[3.3]heptane moiety into candidate molecules to explore structure-activity relationships (SAR) and improve drug-like properties.
• Peptidomimetics & PROTACs: Serves as a building block for designing peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) due to its ability to modulate backbone conformation.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological targets and pathways.
• Process Chemistry: Employed in route scouting and scale-up synthesis for the commercial manufacturing of complex therapeutic agents.
• Academic & Industrial R&D: Fundamental research reagent in universities and corporate labs for exploring new chemical space in heterocyclic and spirocyclic chemistry.

Basic Information

Product Name	1-Boc-1-Azaspiro[3.3]Heptane-6-Carboxylic Acid
CAS No.	1374659-11-6
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]-1-azaspiro[3.3]heptane-6-carboxylic acid; tert-Butyl 6-carboxy-1-azaspiro[3.3]heptane-1-carboxylate; 1-Boc-1-azaspiro[3.3]heptane-6-carboxylic acid; 1-Azaspiro[3.3]heptane-6-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; 1-N-Boc-1-azaspiro[3.3]heptane-6-carboxylic acid; Boc-1-Azaspiro[3.3]heptane-6-COOH; Spirocyclic Boc-protected amino acid
EINECS	Contact for details

Quality Control

Our 1-Boc-1-Azaspiro[3.3]Heptane-6-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity suitable for demanding research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.