Description

6-(tert-Butoxycarbonyl)-6-Azaspiro[3.5]Nonane-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and Boc-protected amine structure. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with complex molecular architectures. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring constrained peptidomimetics and bioactive scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog for creating peptide-like molecules with enhanced metabolic stability.
• Protease Inhibitor Development: Foundational scaffold for designing inhibitors targeting various protease enzymes.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules under cGMP conditions.

Basic Information

Product Name	6-(tert-Butoxycarbonyl)-6-Azaspiro[3.5]Nonane-2-Carboxylic Acid
CAS No.	1374659-03-6
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	6-[(tert-Butoxy)carbonyl]-6-azaspiro[3.5]nonane-2-carboxylic acid; 6-Boc-6-azaspiro[3.5]nonane-2-carboxylic acid; 6-(Boc)-6-Azaspiro[3.5]nonane-2-Carboxylic Acid; 2-Carboxy-6-azaspiro[3.5]nonane-6-carboxylic acid tert-butyl ester; tert-Butyl 2-carboxy-6-azaspiro[3.5]nonane-6-carboxylate; 6-N-Boc-6-azaspiro[3.5]nonane-2-carboxylic acid; Boc-6-Azaspiro[3.5]nonane-2-COOH; 1374659-03-6
EINECS	Contact for details

Quality Control

Our 6-(tert-Butoxycarbonyl)-6-Azaspiro[3.5]Nonane-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for advanced pharmaceutical intermediates, ensuring suitability for demanding R&D and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.