Description

Azido-Peg1-T-Butyl Ester is a specialized bifunctional PEG linker featuring an azide group and a protected carboxylic acid. This compound is critical for facilitating click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the precise conjugation of biomolecules and materials. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science who require reliable, high-purity building blocks for creating novel drug delivery systems, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Used as a key linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) synthesis.
• Peptide and Protein Modification: Enables site-specific labeling or functionalization of peptides and proteins via click chemistry.
• Polymer and Material Science: Serves as a monomer or cross-linker for creating functionalized hydrogels, surfaces, and smart materials with azide handles.
• Diagnostic Reagent Synthesis: Facilitates the production of fluorescent probes, MRI contrast agents, and other diagnostic tools.
• Prodrug Synthesis: Utilized in designing prodrugs where the t-butyl ester acts as a cleavable protecting group for controlled drug release.
• Chemical Biology Research: A fundamental tool for studying biomolecular interactions and cellular processes through bioorthogonal chemistry.

Basic Information

Product Name	Azido-Peg1-T-Butyl Ester
CAS No.	1374658-85-1
Molecular Formula	C9H17N3O3
Molecular Weight	215.25 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]acetic acid tert-butyl ester; tert-Butyl 2-[2-(2-azidoethoxy)ethoxy]acetate; Azido-PEG1-t-butyl ester; Azido-PEG1-OtBu; 2,5,8-Trioxa-11-azadodecan-12-oic acid, 11-azido-, 1,1-dimethylethyl ester; PEG1 azide t-butyl ester; Azido-EG1-t-butyl ester; N3-PEG1-COOtBu
EINECS	Contact for details

Quality Control

Our Azido-Peg1-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade materials for preclinical and clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. The material is highly volatile and moisture-sensitive; ensure containers are sealed and desiccated upon opening. For long-term storage, keep the primary container in a secondary, sealed vessel.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.