Description

Propargyl-Peg3-T-Butyl Ester is a specialized bifunctional PEG linker featuring a terminal propargyl group and a tert-butyl ester. This compound is a critical building block in modern bioconjugation and materials science, enabling the precise attachment of molecules via click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications ranging from drug delivery systems to polymer synthesis.

Application

• Bioconjugation Reagent: Used for site-specific labeling of peptides, proteins, and antibodies via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component for attaching cytotoxic payloads to monoclonal antibodies.
• Polymer & Dendrimer Synthesis: Acts as a functional monomer or crosslinker for creating PEGylated polymers with tailored properties.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and diagnostic assay surfaces with bio-orthogonal handles.
• Proteomics Research: Enables the enrichment and identification of labeled biomolecules in activity-based protein profiling (ABPP).
• Prodrug Design: Incorporated into prodrug constructs where the tert-butyl ester can be cleaved under specific conditions to release an active drug.

Basic Information

Product Name	Propargyl-Peg3-T-Butyl Ester
CAS No.	1374658-84-0
Molecular Formula	C16H28O6
Molecular Weight	316.39 g/mol
Synonyms	Propargyl-PEG3-t-butyl ester; 3,6,9-Trioxa-12-azatetradec-13-ynoic acid, 1,1-dimethylethyl ester; tert-Butyl 2,5,8,11-tetraoxatetradec-13-yn-14-oate; Propargyl-PEG3-OtBu; Propargyl-PEG3-tBu ester; 1-tert-Butyl 14-propargyl 3,6,9,12-tetraoxatetradecanedioate; Propargyl-PEG3-acid t-butyl ester; Alkyne-PEG3-t-butyl ester
EINECS	Contact for details

Quality Control

Our Propargyl-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research and cGMP-grade standards. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.