Description

5-(Trifluoromethyl)-2-Methoxy-3-Vinylpyridine CAS NO 1374652-36-4 is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine core substituted with trifluoromethyl, methoxy, and vinyl functional groups. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in the areas of oncology, neurology, and antiviral treatments.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex drug molecules, especially those targeting protein kinases and other enzymes.
• Agrochemical Research: Used in the discovery and synthesis of novel pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic electronic materials.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create labeled compounds and probes for studying biological pathways and target engagement.

Basic Information

Product Name	5-(Trifluoromethyl)-2-Methoxy-3-Vinylpyridine
CAS No.	1374652-36-4
Molecular Formula	C9H8F3NO
Molecular Weight	203.16 g/mol
Synonyms	2-Methoxy-3-vinyl-5-(trifluoromethyl)pyridine; 3-Vinyl-2-methoxy-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-methoxy-3-vinylpyridine; 2-Methoxy-5-(trifluoromethyl)-3-vinylpyridine; 3-Ethenyl-2-methoxy-5-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-2-Methoxy-3-Vinylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid or clear to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.