Description

3-Amino-5-Fluoropyridine-2-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its reactive amino, fluoro, and nitrile groups. This compound matters for its critical role in the synthesis of complex molecules, offering a versatile scaffold for constructing pharmacologically active cores. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its fluorine-substituted pyridine core.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: The halogen and amino groups make it a suitable substrate for various palladium-catalyzed cross-coupling reactions.
• Heterocyclic Chemistry: A versatile starting material for the construction of more complex fused-ring systems like pyrrolopyridines and imidazopyridines.

Basic Information

Product Name	3-Amino-5-Fluoropyridine-2-Carbonitrile
CAS No.	1374115-60-2
Molecular Formula	C6H4FN3
Molecular Weight	137.12 g/mol
Synonyms	2-Cyano-5-fluoro-3-aminopyridine; 5-Fluoro-3-aminopicolinonitrile; 3-Amino-5-fluoropicolinonitrile; 5-Fluoro-2-cyanopyridin-3-amine; 3-Amino-5-fluoro-2-pyridinecarbonitrile; 2-Pyridinecarbonitrile, 3-amino-5-fluoro-; 1374115-60-2
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Fluoropyridine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.