Description

2-(tert-Butoxycarbonyl)-5-Thia-2-Azaspiro[3.4]Octane-8-Carboxylic Acid (Wx101020) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with potential biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting various disease pathways.
• Protease Inhibitor Research: Used in the development of inhibitors for proteolytic enzymes, relevant to antiviral and anticancer drug discovery.
• Peptidomimetic Chemistry: Serves as a constrained, non-peptide backbone mimic to enhance metabolic stability and bioavailability of peptide-based drug candidates.
• Chemical Biology Probes: Employed in the construction of specialized molecular probes for studying enzyme function and protein-protein interactions.
• Library Synthesis for High-Throughput Screening: A valuable scaffold for generating diverse compound libraries to identify new lead structures in drug discovery campaigns.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of development candidates.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-5-Thia-2-Azaspiro[3.4]Octane-8-Carboxylic Acid (Wx101020)
CAS No.	1373029-39-0
Molecular Formula	C12H19NO4S
Molecular Weight	273.35 g/mol
Synonyms	8-Carboxy-2-(tert-butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane; tert-Butyl 8-carboxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate; 2-Boc-5-thia-2-azaspiro[3.4]octane-8-carboxylic acid; Wx101020; 5-Thia-2-azaspiro[3.4]octane-8-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; Spirocyclic Thiaza Building Block; Boc-Protected Spirocyclic Amino Acid Derivative
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-5-Thia-2-Azaspiro[3.4]Octane-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.