Description

tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate is a high-purity, protected boronic ester derivative of a pyrrolopyridine heterocycle, serving as a critical advanced pharmaceutical intermediate for modern drug discovery. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for medicinal chemistry researchers and process development scientists in the pharmaceutical and agrochemical industries seeking to develop novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Enables the rapid exploration of structure-activity relationships (SAR) by facilitating the introduction of the pyrrolopyridine moiety into diverse molecular architectures via cross-coupling.
• Agrochemical Development: Used in the research and synthesis of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science Precursor: Potential intermediate in the development of organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology Probes: Serves as a synthetic handle for creating molecular probes to study biological processes and protein interactions.
• Process Chemistry & Scale-up: Supports the transition from laboratory-scale discovery to commercial manufacturing processes for new chemical entities.

Basic Information

Product Name	tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate
CAS No.	1370616-23-1
Molecular Formula	C18H25BN2O4
Molecular Weight	344.22 g/mol
Synonyms	1-Boc-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-(pinacolatoboryl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 5-Pinacolatoboryl-1-Boc-7-azaindole
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.