Description

2-Chloro-4-Fluoro-5-Iodopyridine is a high-purity halogenated pyridine derivative, serving as a critical multi-functional building block in advanced organic synthesis. Its unique substitution pattern makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry for creating libraries of novel heterocyclic compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science: Employed in the research and production of advanced organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology: Useful as a probe or labeling agent due to the presence of the iodine atom, which can be used for further functionalization via halogen exchange.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specific halogenated pyridine intermediates.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-Iodopyridine
CAS No.	1370534-60-3
Molecular Formula	C5H2ClFIN
Molecular Weight	272.43 g/mol
Synonyms	5-Iodo-2-chloro-4-fluoropyridine; 2-Chloro-4-fluoro-5-iodopyridine; Pyridine, 2-chloro-4-fluoro-5-iodo-; 4-Fluoro-2-chloro-5-iodopyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-5-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.