Description

7-Azaspiro[3.5]Nonane-7-Carboxylic Acid, 2-(2-Hydroxyethyl)-, 1,1-Dimethylethyl Ester is a high-value, protected amino acid derivative featuring a unique spirocyclic and functionalized side chain architecture. This compound is a critical advanced intermediate in modern pharmaceutical synthesis, enabling the construction of complex molecules with precise stereochemistry. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting neurological receptors and enzymes.
• Peptidomimetics & Constrained Peptides: Used to introduce rigid, spirocyclic motifs into peptide backbones to enhance metabolic stability and biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological pathways and protein function.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential commercial drug substances.

Basic Information

Product Name	7-Azaspiro[3.5]Nonane-7-Carboxylic Acid, 2-(2-Hydroxyethyl)-, 1,1-Dimethylethyl Ester
CAS No.	1370210-93-7
Molecular Formula	C14H25NO3
Molecular Weight	255.36 g/mol
Synonyms	tert-Butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]nonane-7-carboxylate; 2-(2-Hydroxyethyl)-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester; 7-Boc-2-(2-hydroxyethyl)-7-azaspiro[3.5]nonane; 7-(tert-Butoxycarbonyl)-2-(2-hydroxyethyl)-7-azaspiro[3.5]nonane; N-Boc-2-(2-hydroxyethyl)-7-azaspiro[3.5]nonane; (2-(2-Hydroxyethyl)-7-azaspiro[3.5]nonan-7-yl)(tert-butoxy)methanone
EINECS	Contact for details

Quality Control

Our 7-Azaspiro[3.5]Nonane-7-Carboxylic Acid, 2-(2-Hydroxyethyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.