Description

2,5-Dioxopyrrolidin-1-Yl Tetrahydro-2H-Pyran-4-Carboxylate is a high-purity, activated ester derivative used as a key synthetic intermediate. Its primary value lies in its reactivity as an acylating agent, enabling efficient amide bond formation under mild conditions, which is critical for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of active pharmaceutical ingredients (APIs), peptide synthesis, and the creation of novel chemical entities for drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Coupling Reagent: Facilitates amide bond formation in solid-phase and solution-phase peptide synthesis.
• Bioconjugation Chemistry: Used for labeling biomolecules (e.g., proteins, antibodies) with probes, drugs, or other functional groups.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialized functional polymers.
• Organic Synthesis: Employed as an activated ester for introducing the tetrahydro-2H-pyran-4-carbonyl moiety into target molecules.
• Proteomics Research: Utilized in chemical proteomics for activity-based protein profiling and target identification.
• Material Science: Applied in the surface functionalization of nanomaterials and other advanced materials.

Basic Information

Product Name	2,5-Dioxopyrrolidin-1-Yl Tetrahydro-2H-Pyran-4-Carboxylate
CAS No.	1369515-33-2
Molecular Formula	C10H13NO5
Molecular Weight	227.21 g/mol
Synonyms	N-Hydroxysuccinimide Tetrahydro-2H-pyran-4-carboxylate; NHS-THP Ester; THP-Carboxylic Acid N-Succinimidyl Ester; 1-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-4-oxo-1-oxypentyl; Tetrahydro-2H-pyran-4-carboxylic Acid N-Succinimidyl Ester; 4-((2,5-Dioxopyrrolidin-1-yl)oxy)-4-oxotetrahydro-2H-pyran-4-carboxylic Acid (incorrect but common search variant); Activated THP Ester
EINECS	Contact for details

Quality Control

Our 2,5-Dioxopyrrolidin-1-Yl Tetrahydro-2H-Pyran-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.