Description

4-Fluoro-2,3-Dihydrospiro[Indene-1,3'-Piperidine] is a high-value spirocyclic organic compound featuring a unique fused indene and piperidine structure with a fluorine substituent. This molecular architecture makes it a critical advanced pharmaceutical intermediate (API) and a versatile scaffold in modern drug discovery. It is primarily utilized by research and development organizations in the pharmaceutical and agrochemical sectors for the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a privileged scaffold in high-throughput screening and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Agrochemical Development: Acts as a precursor in the research and synthesis of new-generation pesticides and herbicides with enhanced efficacy.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and receptor interactions in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring complex spirocyclic frameworks.

Basic Information

Product Name	4-Fluoro-2,3-Dihydrospiro[Indene-1,3'-Piperidine]
CAS No.	1369495-76-0
Molecular Formula	C13H16FN
Molecular Weight	205.27 g/mol
Synonyms	4-Fluoro-2,3-dihydrospiro[indene-1,3'-piperidine]; 4-Fluoro-2,3-dihydro-1'H-spiro[indene-1,3'-piperidine]; 4-Fluoro-1'H-spiro[indene-1,3'-piperidine]; 4-Fluoro-spiro[indane-1,3'-piperidine]; 1369495-76-0; Spiro[indene-1,3'-piperidine], 4-fluoro-2,3-dihydro-; 4-Fluoro-2,3-dihydro-1H-spiro[indene-1,3'-piperidine]
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-2,3-Dihydrospiro[Indene-1,3'-Piperidine] adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and current industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.