Description

tert-Butyl 2-Oxa-5,8-Diazaspiro[3.5]Nonane-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential therapeutic activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker component in the design of bifunctional degraders, leveraging its heterocyclic and functionalized nature.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Used in the development of robust and scalable synthetic routes for GMP production of clinical trial materials.

Basic Information

Product Name	tert-Butyl 2-Oxa-5,8-Diazaspiro[3.5]Nonane-5-Carboxylate
CAS No.	1367936-05-7
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	5-[(1,1-Dimethylethoxy)carbonyl]-2-oxa-5,8-diazaspiro[3.5]nonane; 2-Oxa-5,8-diazaspiro[3.5]nonane-5-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 2-oxa-5,8-diazaspiro[3.5]nonane-5-carboxylate; 5-Boc-2-oxa-5,8-diazaspiro[3.5]nonane; Boc-ODAN; 1367936-05-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Oxa-5,8-Diazaspiro[3.5]Nonane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.