Description

2-Oxa-5-Azaspiro[3.5]Nonane-5-Carboxylic Acid, 8-Amino-, 1,1-Dimethylethyl Ester is a high-value, multifunctional spirocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular scaffolds to develop novel active pharmaceutical ingredients (APIs) and agrochemicals. Its unique structure, featuring both amino and ester-protected carboxylic acid functionalities, makes it an essential intermediate for medicinal chemistry, particularly in the synthesis of complex heterocycles and constrained peptidomimetics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used to introduce the constrained 2-oxa-5-azaspiro[3.5]nonane scaffold into molecules to modulate physicochemical properties and biological activity.
• Agrochemical Synthesis: Intermediate in the development of new-generation herbicides and fungicides with novel modes of action.
• Peptidomimetic Development: Serves as a conformationally restricted amino acid analog for creating stable peptide-like molecules.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.

Basic Information

Item	Details
Product Name	2-Oxa-5-Azaspiro[3.5]Nonane-5-Carboxylic Acid, 8-Amino-, 1,1-Dimethylethyl Ester
CAS No.	1367679-67-1
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	tert-Butyl 8-amino-2-oxa-5-azaspiro[3.5]nonane-5-carboxylate; 8-Amino-2-oxa-5-azaspiro[3.5]nonane-5-carboxylic acid tert-butyl ester; 5-Boc-8-amino-2-oxa-5-azaspiro[3.5]nonane; Boc-8-amino-2-oxa-5-azaspiro[3.5]nonane; 1367679-67-1; 2-Oxa-5-azaspiro[3.5]nonane-5-carboxylic acid, 8-amino-, 1,1-dimethylethyl ester; Spirocyclic amino ester building block
EINECS	Contact for details

Quality Control

Our production of 2-Oxa-5-Azaspiro[3.5]Nonane-5-Carboxylic Acid, 8-Amino-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.