Description

6-Oxa-2,9-Diaza-Spiro[4.5]Decane-2-Carboxylicacidtert-Butylester (Wx100458) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting complex biological pathways. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those requiring complex heterocyclic architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API synthesis under cGMP conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential application as a linker or component in the design of bifunctional degraders.
• Chemical Biology Probes: Useful for creating tool compounds to study enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of specialized, high-value compounds for clinical trials.

Basic Information

Product Name	6-Oxa-2,9-Diaza-Spiro[4.5]Decane-2-Carboxylicacidtert-Butylester (Wx100458)
CAS No.	1366647-28-0
Molecular Formula	C12H21N3O3
Molecular Weight	255.31 g/mol
Synonyms	tert-Butyl 6-oxa-2,9-diazaspiro[4.5]decane-2-carboxylate; 2,9-Diaza-6-oxaspiro[4.5]decane-2-carboxylic acid, 1,1-dimethylethyl ester; WX-100458; Wx100458; 6-Oxa-2,9-diazaspiro[4.5]decane-2-carboxylic acid tert-butyl ester; Spirocyclic tert-butyl ester intermediate; 1366647-28-0
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and released with a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to strict internal quality management protocols to ensure batch-to-batch consistency and reliability for your critical R&D and scale-up projects. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.