Description

4,4-Difluoro-1,4-Bipiperidine 2Hcl CAS NO 1364631-70-8 is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated bipiperidine core structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) where its unique fluorine-substituted scaffold can enhance metabolic stability and bioavailability. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers developing next-generation therapeutics and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Scaffold: Used for structure-activity relationship (SAR) studies and lead optimization due to its difluorinated piperidine motifs.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides with improved efficacy.
• Ligand Synthesis: Employed in the creation of complex ligands for catalysis and chemical synthesis.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological systems and enzyme function.
• Fine Chemical Production: An intermediate for manufacturing specialized, high-value chemicals for research and industrial applications.

Basic Information

Product Name	4,4-Difluoro-1,4-Bipiperidine 2Hcl
CAS No.	1364631-70-8
Molecular Formula	C10H18F2N2 • 2HCl
Molecular Weight	281.18 g/mol (Free base: 204.26 g/mol)
Synonyms	1,1'-(1,4-Piperazinediyl)bis[4-fluoropiperidine] dihydrochloride; 4,4'-Difluoro-1,4'-bipiperidine dihydrochloride; 4-Fluoro-1-(4-fluoropiperidin-1-yl)piperidine dihydrochloride; 1,4-Bis(4-fluoropiperidin-1-yl)piperazine dihydrochloride; 4,4-Difluoro-1,4'-bipiperidine 2HCl; 1364631-70-8; 4,4-Difluoro-1,4-bipiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1,4-Bipiperidine 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.