Description

9-Boc-2-Oxo-3-Oxa-1,9-Diaza-Spiro[5.5]Undecane is a sophisticated spirocyclic organic building block featuring a protected amine (Boc) and a lactam moiety, making it a valuable intermediate for advanced pharmaceutical synthesis. Its rigid, three-dimensional structure is crucial for medicinal chemistry research, particularly in the development of novel drug candidates targeting complex biological pathways. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality building blocks for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Protease Inhibitor Research: Used in the development of protease inhibitors, leveraging its spirocyclic lactam structure as a core scaffold.
• Chemical Biology & Probe Development: Serves as a versatile scaffold for creating chemical probes to study enzyme function and protein-protein interactions.
• Peptidomimetic Synthesis: Employed to construct constrained peptidomimetics, which are designed to mimic peptides but with enhanced metabolic stability and bioavailability.
• Library Synthesis for Drug Discovery: Utilized in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Sourced for process research and development (PR&D) and pilot-scale manufacturing of clinical trial materials.

Basic Information

Product Name	9-Boc-2-Oxo-3-Oxa-1,9-Diaza-Spiro[5.5]Undecane
CAS No.	1363383-43-0
Molecular Formula	C13H22N2O4
Molecular Weight	270.33 g/mol
Synonyms	tert-Butyl 2-oxo-3-oxa-1,9-diazaspiro[5.5]undecane-9-carboxylate; 1,9-Diazaspiro[5.5]undecane-2-one, 9-(1,1-dimethylethyl) 3-oxa- ester; 9-Boc-1,9-diaza-2-oxaspiro[5.5]undecan-3-one; 9-(tert-Butoxycarbonyl)-2-oxo-3-oxa-1,9-diazaspiro[5.5]undecane; BOC-ONASU; Spirocyclic Boc-protected lactam
EINECS	Contact for details

Quality Control

Our 9-Boc-2-Oxo-3-Oxa-1,9-Diaza-Spiro[5.5]Undecane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support our clients' regulatory needs and can supply material suitable for research and development under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.