Description

tert-Butyl 7-Hydroxy-2-azaspiro[3.5]nonane-2-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) and GPCR-related pathways.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in bifunctional degrader molecules.
• Chemical Biology Probes: Employed in the development of selective enzyme inhibitors or receptor modulators for biological pathway elucidation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 7-Hydroxy-2-azaspiro[3.5]nonane-2-carboxylate
CAS No.	1363383-18-9
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	2-Azaspiro[3.5]nonane-2-carboxylic acid, 7-hydroxy-, 1,1-dimethylethyl ester; 7-Hydroxy-2-azaspiro[3.5]nonane-2-carboxylic acid tert-butyl ester; tert-Butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate; Boc-7-hydroxy-2-azaspiro[3.5]nonane; 1363383-18-9; 7-Hydroxy-2-azaspiro[3.5]nonane-2-carboxylic acid, tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Hydroxy-2-azaspiro[3.5]nonane-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.