Description

Methyl 1-Boc-3-Fluoroazetidine-3-Carboxylate is a high-value, fluorinated azetidine building block crucial for modern pharmaceutical and agrochemical research. Its core value lies in the unique 3-fluoroazetidine scaffold, which is increasingly sought after for its ability to modulate the physicochemical and metabolic properties of bioactive molecules. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical industry, particularly those developing novel therapeutics in areas such as oncology, CNS disorders, and anti-infectives, where the introduction of fluorine and constrained ring systems is a key strategy.

Application

• Pharmaceutical Intermediate: A critical precursor for the synthesis of active pharmaceutical ingredients (APIs) containing the 3-fluoroazetidine moiety.
• Medicinal Chemistry & Drug Discovery: Used as a versatile building block in SAR (Structure-Activity Relationship) studies and lead optimization to improve potency, selectivity, and metabolic stability.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in bifunctional degrader molecules.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or insecticides that benefit from fluorinated heterocycles.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function or biological pathways.
• Process Chemistry & Scale-up: Provides a protected, esterified form suitable for multi-step synthesis and potential commercial-scale manufacturing routes.

Basic Information

Product Name	Methyl 1-Boc-3-Fluoroazetidine-3-Carboxylate
CAS No.	1363382-00-6
Molecular Formula	C10H16FNO4
Molecular Weight	233.24 g/mol
Synonyms	1-Boc-3-fluoroazetidine-3-carboxylic acid methyl ester; 3-Fluoro-1-[(tert-butoxy)carbonyl]azetidine-3-carboxylic acid methyl ester; tert-Butyl 3-fluoro-3-(methoxycarbonyl)azetidine-1-carboxylate; Methyl 3-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylate; 1-Boc-3-fluoroazetidine-3-methyl carboxylate; 3-Fluoroazetidine-3-carboxylic acid methyl ester, 1-Boc protected
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.