Description

cis-tert-Butyl 3-Hydroxy-2,2,4,4-(Tetramethyl)Cyclobutylcarbamate is a high-purity, synthetically derived carbamate derivative featuring a sterically hindered cyclobutane core. This compound matters as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile chiral building block for complex organic synthesis. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly for complex target molecules.
• Agrochemical Synthesis: Serves as a precursor or building block for developing advanced crop protection agents and herbicides with specific stereochemical requirements.
• Organic Synthesis Building Block: Utilized in academic and industrial research for constructing complex, sterically hindered molecular architectures due to its rigid cyclobutane structure.
• Ligand and Catalyst Development: Potential use in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Investigated as a monomer or additive for creating polymers with unique thermal and mechanical properties.

Basic Information

Product Name	cis-tert-Butyl 3-Hydroxy-2,2,4,4-(Tetramethyl)Cyclobutylcarbamate
CAS No.	1363381-85-4
Molecular Formula	C13H25NO3
Molecular Weight	243.34 g/mol
Synonyms	tert-Butyl (1r,3s)-3-hydroxy-2,2,4,4-tetramethylcyclobutane-1-carboxylate; (1r,3s)-3-Hydroxy-2,2,4,4-tetramethylcyclobutane-1-carboxylic acid tert-butyl ester; cis-3-Hydroxy-2,2,4,4-tetramethylcyclobutylcarbamic acid tert-butyl ester; BOC-protected 3-hydroxy-TMCB; TMCB-OH BOC ester; 1363381-85-4; Carbamic acid, N-(3-hydroxy-2,2,4,4-tetramethylcyclobutyl)-, 1,1-dimethylethyl ester, cis-
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl 3-Hydroxy-2,2,4,4-(Tetramethyl)Cyclobutylcarbamate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral analysis, to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.