Description

1-Boc-6-Hydroxy-1-Azaspiro[3.3]heptane is a high-value, protected heterocyclic building block featuring a unique spirocyclic and hydroxylated azetidine-like structure. This compound is critical for medicinal chemistry research, enabling the rapid synthesis of novel, three-dimensional scaffolds with improved drug-like properties. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing new therapeutic candidates, particularly in areas requiring complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel active pharmaceutical ingredients (APIs) with spirocyclic motifs.
• Medicinal Chemistry Research: Used in fragment-based drug discovery and lead optimization to explore new chemical space and improve pharmacokinetic profiles.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its rigid spiro structure and functional handles (Boc and OH groups).
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance metabolic stability and conformational rigidity.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for target identification and validation studies.
• Agrochemical Research: Potential intermediate for developing new crop protection agents with novel modes of action.

Basic Information

Product Name	1-Boc-6-Hydroxy-1-Azaspiro[3.3]heptane
CAS No.	1363381-56-9
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	tert-Butyl 6-hydroxy-1-azaspiro[3.3]heptane-1-carboxylate; 1-(tert-Butoxycarbonyl)-6-hydroxy-1-azaspiro[3.3]heptane; 1-Azaspiro[3.3]heptane-6-ol, 1-(1,1-dimethylethoxy)carbonyl]-; 1-Boc-6-hydroxy-1-azaspiro[3.3]heptane; 6-Hydroxy-1-azaspiro[3.3]heptane-1-carboxylic acid tert-butyl ester; 1-N-Boc-6-hydroxy-1-azaspiro[3.3]heptane; 1-(tert-Butyloxycarbonyl)-6-hydroxy-1-azaspiro[3.3]heptane
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Hydroxy-1-Azaspiro[3.3]heptane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.