Description

2-(Boc-Amino)-5-Aza-Spiro[3.4]Octane CAS NO 1363381-16-1 is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential therapeutic activity. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel drug candidates, particularly in areas requiring constrained, three-dimensional molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warhead attachments in bifunctional degrader molecules.
• Chemical Biology Probes: Incorporated into tool compounds for studying biological pathways and target validation.
• Peptidomimetic Synthesis: The spirocyclic and aza-moieties make it valuable for creating conformationally restricted peptide mimics.
• Library Synthesis for High-Throughput Screening (HTS): Used to generate diverse compound libraries for screening against novel biological targets.

Basic Information

Product Name	2-(Boc-Amino)-5-Aza-Spiro[3.4]Octane
CAS No.	1363381-16-1
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	5-Azaspiro[3.4]octan-2-amine, N-Boc-; tert-Butyl (5-azaspiro[3.4]octan-2-yl)carbamate; 2-((tert-Butoxycarbonyl)amino)-5-azaspiro[3.4]octane; N-Boc-5-azaspiro[3.4]octan-2-amine; 2-(Boc-amino)-5-aza-spiro[3.4]octane; Boc-5-Azaspiro[3.4]octan-2-amine; 1363381-16-1; 2-Amino-5-azaspiro[3.4]octane Boc-protected
EINECS	Contact for details

Quality Control

Every batch of 2-(Boc-Amino)-5-Aza-Spiro[3.4]Octane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with each shipment and are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.