Description

tert-Butyl 6-Oxo-1-Azaspiro[3.3]heptane-1-carboxylate is a high-value, protected spirocyclic intermediate of significant interest in modern synthetic organic chemistry. This compound matters because it provides a versatile and constrained scaffold that is crucial for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical R&D teams and fine chemical manufacturers need this building block for its role in synthesizing potential drug candidates targeting neurological disorders, inflammation, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those requiring a rigid, three-dimensional spirocyclic framework.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linkers and warhead components for targeted protein degradation therapies.
• Medicinal Chemistry & SAR Studies: Serves as a core scaffold for structure-activity relationship exploration to optimize potency and selectivity.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological pathways and target validation.
• Advanced Organic Synthesis: Employed in multi-step syntheses requiring a protected, reactive lactam functionality for further derivatization.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical and biotech innovation pipelines.

Basic Information

Product Name	tert-Butyl 6-Oxo-1-Azaspiro[3.3]heptane-1-carboxylate
CAS No.	1363380-93-1
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	1-Boc-6-Azaspiro[3.3]heptan-6-one; 1-(tert-Butoxycarbonyl)-6-azaspiro[3.3]heptan-6-one; 6-Oxo-1-azaspiro[3.3]heptane-1-carboxylic acid tert-butyl ester; tert-Butyl 6-oxo-1-azaspiro[3.3]heptane-1-carboxylate; 1-N-Boc-6-azaspiro[3.3]heptan-6-one; 1-Azaspiro[3.3]heptane-6-one, 1-(1,1-dimethylethoxy)carbonyl]-; Boc-6-Azaspiro[3.3]heptan-6-one
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Oxo-1-Azaspiro[3.3]heptane-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for advanced research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.