Description

6-Aminomethyl-2-Boc-2-Aza-Spiro[3.3]Heptane is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is a critical building block in modern medicinal chemistry, valued for its ability to impart favorable three-dimensional structural properties and metabolic stability to drug candidates. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in areas targeting the central nervous system and other complex diseases.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linkers and warhead components due to its rigid, three-dimensional geometry.
• Peptidomimetic Chemistry: Incorporated into peptide analogs to enhance metabolic stability, membrane permeability, and receptor binding affinity.
• Kinase Inhibitor Synthesis: Serves as a core structural element in the development of selective kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology & Probe Development: Employed in the creation of tool compounds and molecular probes for target validation and pathway analysis.
• Bioconjugation: The primary amine functionality allows for conjugation to various payloads, fluorophores, or solid supports.

Basic Information

Product Name	6-Aminomethyl-2-Boc-2-Aza-Spiro[3.3]Heptane
CAS No.	1363380-79-3
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-2-azaspiro[3.3]heptane-6-methanamine; 6-(Aminomethyl)-2-[(tert-butoxycarbonyl)amino]-2-azaspiro[3.3]heptane; 2-Aza-spiro[3.3]heptane-2-carboxylic acid, 6-(aminomethyl)-, 1,1-dimethylethyl ester; 2-Boc-2-Aza-spiro[3.3]heptane-6-methylamine; tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate; 6-Aminomethyl-2-N-Boc-2-aza-spiro[3.3]heptane; Boc-Protected 2-Azaspiro[3.3]heptane-6-methylamine
EINECS	Contact for details

Quality Control

Our 6-Aminomethyl-2-Boc-2-Aza-Spiro[3.3]Heptane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring suitability for use in advanced pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.