Description

2-Amino-5-Boc-5-Aza-Spiro[3.4]Octane is a high-value, protected spirocyclic amine building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research and development, serving as a key precursor for constructing complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Scaffold: Used to introduce the constrained spiro[3.4]octane motif, which can improve the potency, selectivity, and metabolic stability of lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a linker or component in the design of bifunctional molecules for targeted protein degradation.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance conformational rigidity and bioavailability.
• Chemical Biology Probes: Used in the creation of tool compounds for studying biological pathways and target validation.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	2-Amino-5-Boc-5-Aza-Spiro[3.4]Octane
CAS No.	1363380-49-7
Molecular Formula	C₁₂H₂₂N₂O₂
Molecular Weight	226.32 g/mol
Synonyms	5-Aza-spiro[3.4]octan-2-amine, 5-(1,1-dimethylethoxy)carbonyl-; tert-Butyl 2-amino-5-aza-spiro[3.4]octane-5-carboxylate; 2-Amino-5-((tert-butoxycarbonyl)-5-aza-spiro[3.4]octane; 5-Boc-2-amino-5-azaspiro[3.4]octane; 5-Azaspiro[3.4]octane-5-carboxylic acid, 2-amino-, 1,1-dimethylethyl ester; Boc-Protected 5-Azaspiro[3.4]octan-2-amine; 1363380-49-7
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Boc-5-Aza-Spiro[3.4]Octane is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full analytical data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.