Description

8-tert-Butyl 2-Methyl 1-Hydroxy-8-Azaspiro[4.5]Decane-2,8-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and azepane structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is primarily sought by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in cutting-edge drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for studying enzyme and receptor functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Used in university laboratories for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	8-tert-Butyl 2-Methyl 1-Hydroxy-8-Azaspiro[4.5]Decane-2,8-Dicarboxylate
CAS No.	1363210-51-8
Molecular Formula	C16H27NO5
Molecular Weight	313.39 g/mol
Synonyms	1-Hydroxy-8-azaspiro[4.5]decane-2,8-dicarboxylic acid, 2-methyl-, 8-(1,1-dimethylethyl) ester; 8-tert-Butyl 2-methyl 1-hydroxy-8-azaspiro[4.5]decane-2,8-dicarboxylate; 8-Azaspiro[4.5]decane-2,8-dicarboxylic acid, 1-hydroxy-, 8-(1,1-dimethylethyl) 2-methyl ester; tert-Butyl 2-methyl 1-hydroxy-8-azaspiro[4.5]decane-2,8-dicarboxylate; CAS 1363210-51-8
EINECS	Contact for details

Quality Control

Our production of 8-tert-Butyl 2-Methyl 1-Hydroxy-8-Azaspiro[4.5]Decane-2,8-Dicarboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our facilities and processes are designed to meet the exacting standards required for pharmaceutical R&D and cGMP intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.