Description

8-tert-Butyl 2-Methyl 8-Azaspiro[4.5]Dec-1-Ene-2,8-Dicarboxylate CAS NO 1363210-32-5 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D departments and custom synthesis organizations for developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• API Development: Serves as a core scaffold for constructing active pharmaceutical ingredients with spirocyclic architectures.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of bespoke compounds for clinical trials.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Process Chemistry: Integral to developing scalable and efficient synthetic routes for potential commercial drug manufacturing.

Basic Information

Product Name	8-tert-Butyl 2-Methyl 8-Azaspiro[4.5]Dec-1-Ene-2,8-Dicarboxylate
CAS No.	1363210-32-5
Molecular Formula	C16H25NO4
Molecular Weight	295.38 g/mol
Synonyms	tert-Butyl 2-methyl 8-azaspiro[4.5]dec-1-ene-2,8-dicarboxylate; 8-Azaspiro[4.5]dec-1-ene-2,8-dicarboxylic acid, 2-methyl-, 1,8-di-tert-butyl ester; 8-(tert-Butoxycarbonyl)-2-methyl-8-azaspiro[4.5]dec-1-ene-2-carboxylic acid methyl ester; Spirocyclic proline derivative; BOC-protected azaspiro compound.
EINECS	Contact for details

Quality Control

Our production of 8-tert-Butyl 2-Methyl 8-Azaspiro[4.5]Dec-1-Ene-2,8-Dicarboxylate adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.