Description

2-Chloro-5-Trifluoromethoxy-Pyridin-4-Ylamine is a high-purity, multi-functional pyridine derivative serving as a critical building block in advanced chemical synthesis. Its value lies in its unique trifluoromethoxy and chloro-substituted pyridine core, which imparts desirable electronic and steric properties for creating novel compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialized ligands, catalysts, and organic electronic materials due to its electron-deficient aromatic system.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom chemical synthesis and scale-up projects for specialized client applications.
• Research & Development: A valuable compound for academic and industrial R&D in medicinal chemistry and organic synthesis for structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Chloro-5-Trifluoromethoxy-Pyridin-4-Ylamine
CAS No.	1361890-39-2
Molecular Formula	C7H4ClF3N2O
Molecular Weight	212.57 g/mol
Synonyms	4-Amino-2-chloro-5-(trifluoromethoxy)pyridine; 2-Chloro-5-(trifluoromethoxy)pyridin-4-amine; 4-Pyridinamine, 2-chloro-5-(trifluoromethoxy)-; 2-Chloro-5-trifluoromethoxypyridin-4-amine; 1361890-39-2; 2-Chloro-5-(trifluoromethoxy)-4-pyridinamine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Trifluoromethoxy-Pyridin-4-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.