Description

6-(tert-Butoxycarbonyl)-6-Azaspiro[2.5]Octane-1-Carboxylic Acid is a high-value, protected spirocyclic amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound matters because it provides a rigid, three-dimensional scaffold essential for constructing complex molecules with precise stereochemistry and enhanced pharmacological properties. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and infectious diseases.
• Peptidomimetic Scaffold: Used to create conformationally constrained peptide analogs, improving metabolic stability and bioavailability in therapeutic peptide design.
• Agrochemical Research: Serves as a building block for developing new crop protection agents with unique modes of action.
• Chemical Biology Probes: Utilized in the construction of molecular probes for studying enzyme function and protein-protein interactions.
• Material Science: Potential monomer for creating specialty polymers with specific structural and functional properties.
• Academic & Contract Research: Essential reagent for methodological development in organic chemistry and asymmetric synthesis laboratories.

Basic Information

Product Name	6-(tert-Butoxycarbonyl)-6-Azaspiro[2.5]Octane-1-Carboxylic Acid
CAS No.	1361202-54-1
Molecular Formula	C₁₃H₂₁NO₄
Molecular Weight	255.31 g/mol
Synonyms	1-[(tert-Butoxy)carbonyl]-6-azaspiro[2.5]octane-6-carboxylic acid; Boc-6-Azaspiro[2.5]octane-1-carboxylic Acid; 6-(Boc)-6-Azaspiro[2.5]octane-1-carboxylic Acid; 6-Azaspiro[2.5]octane-1-carboxylic acid, 6-[(1,1-dimethylethoxy)carbonyl]-; 6-N-Boc-6-azaspiro[2.5]octane-1-carboxylic acid; tert-Butyl 1-carboxy-6-azaspiro[2.5]octane-6-carboxylate; 6-Azaspiro[2.5]octane-1-carboxylic acid, N-Boc-protected; CAS 1361202-54-1
EINECS	Contact for details

Quality Control

Our 6-(tert-Butoxycarbonyl)-6-Azaspiro[2.5]Octane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.