Description

5-Methyl-1H-Spiro[Cyclopropane-1,3-Indole]-2-One is a high-value, spirocyclic indole derivative, a sophisticated organic building block prized for its unique three-dimensional structure. This compound matters as a critical intermediate in modern pharmaceutical research and development, enabling the synthesis of novel drug candidates with potentially enhanced biological activity and metabolic stability. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for applications in drug discovery programs, particularly those targeting central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel small-molecule therapeutics.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening (HTS) campaigns.
• Drug Discovery: Employed in the synthesis of potential drug candidates targeting complex protein receptors and enzymes.
• Chemical Biology: Serves as a probe or tool compound for studying biological pathways and protein-ligand interactions.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in universities and research institutes for studies in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	5-Methyl-1H-Spiro[Cyclopropane-1,3-Indole]-2-One
CAS No.	1360946-84-4
Molecular Formula	C11H11NO
Molecular Weight	173.21 g/mol
Synonyms	5-Methyl-1H-spiro[cyclopropane-1,3'-indol]-2'(1'H)-one; 5-Methylspiro[cyclopropane-1,3'-indolin]-2'-one; 5-Methyl-1'H-spiro[cyclopropane-1,3'-indole]-2'-one; 5-Methyl-1H-spiro[cyclopropane-1,3-indol]-2(1H)-one; 1360946-84-4; Spiro[cyclopropane-1,3'-indolin]-2'-one, 5-methyl-; 5-Methyl-1H-spiro[cyclopropane-1,3-indole]-2-one
EINECS	Contact for details

Quality Control

Our 5-Methyl-1H-Spiro[Cyclopropane-1,3-Indole]-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.