Description

7-Bromo-1H-Spiro[Cyclopropane-1,3-Indole]-2-One is a high-value, spirocyclic indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for researchers and manufacturers developing novel pharmaceuticals and agrochemicals due to its unique, rigid molecular framework. It is particularly valuable for medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas, where its structure enables the exploration of new chemical space.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for CNS-targeted therapies, kinase inhibitors, and other small molecule pharmaceuticals.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization stages to introduce the spiro[cyclopropane-1,3'-indole] scaffold, which can improve metabolic stability and binding affinity.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new generation pesticides and herbicides with novel modes of action.
• Chemical Biology Probe Synthesis: Utilized to create specialized molecular probes for studying biological pathways and protein function.
• Material Science Research: Investigated as a monomer or precursor for advanced organic electronic materials and specialty polymers.

Basic Information

Product Name	7-Bromo-1H-Spiro[Cyclopropane-1,3-Indole]-2-One
CAS No.	1360935-49-4
Molecular Formula	C10H6BrNO
Molecular Weight	236.07 g/mol
Synonyms	7-Bromo-1H-spiro[cyclopropane-1,3'-indol]-2'(1'H)-one; 7-Bromospiro[cyclopropane-1,3'-indolin]-2'-one; 7-Bromo-1'H-spiro[cyclopropane-1,3'-indole]-2'-one; 7-Bromo-2-oxo-1,2-dihydrospiro[cyclopropane-1,3'-indole]; 1360935-49-4; Spiro[cyclopropane-1,3'-indole]-2'-one, 7'-bromo-; 7-Bromo-1H-spiro[cyclopropane-1,3-indol]-2(3H)-one
EINECS	Contact for details

Quality Control

Our 7-Bromo-1H-Spiro[Cyclopropane-1,3-Indole]-2-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.