Description

(S)-2-(3-Fluorophenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical research and development. Its core value lies in providing a structurally defined, enantiomerically pure scaffold for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating targeted molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) targets.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective chemical reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core structural motif for structure-activity relationship (SAR) studies and lead optimization programs.
• Agrochemical Development: Employed in the synthesis of novel, enantiomerically pure pesticides and herbicides.
• Reference Standard: Utilized as an analytical standard for method development and quality control in chiral separation techniques like HPLC.
• Chemical Biology Probes: Acts as a building block for creating molecular probes to study biological pathways and enzyme functions.

Basic Information

Product Name	(S)-2-(3-Fluorophenyl)Pyrrolidine Hydrochloride
CAS No.	1360442-16-5
Molecular Formula	C10H13FN•HCl
Molecular Weight	201.68 g/mol (Free base: 165.22 g/mol)
Synonyms	(S)-2-(3-Fluorophenyl)pyrrolidine HCl; (S)-3-Fluoro-α-(pyrrolidin-2-yl)benzene hydrochloride; (S)-2-(3-Fluorophenyl)-1-azacyclopentane hydrochloride; (S)-2-(m-Fluorophenyl)pyrrolidine hydrochloride; (S)-(-)-2-(3-Fluorophenyl)pyrrolidine hydrochloride; Pyrrolidine, 2-(3-fluorophenyl)-, (2S)-, hydrochloride; 1360442-16-5; (S)-2-(3-Fluorophenyl)pyrrolidine HCl salt
EINECS	Contact for details

Quality Control

Our (S)-2-(3-Fluorophenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee supply reliability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.