Description

5-Amino-2-Chloroisonicotinonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, featuring both an amino and a chloro substituent on a cyanopyridine scaffold, which enables precise and diverse derivatization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a critical precursor for developing novel active ingredients and complex molecular frameworks.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging its heterocyclic reactivity.
• Ligand and Catalyst Development: Serves as a precursor for constructing specialized ligands used in catalytic processes and material science.
• Functional Material Research: Employed in the synthesis of organic electronic materials and dyes due to its electron-deficient pyridine core.
• Chemical Biology Probes: Utilized to build molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis and R&D: A versatile starting material for contract research organizations and fine chemical companies engaged in custom synthesis projects.

Basic Information

Product Name	5-Amino-2-Chloroisonicotinonitrile
CAS No.	1359828-87-7
Molecular Formula	C6H4ClN3
Molecular Weight	153.57 g/mol
Synonyms	2-Chloro-5-aminopyridine-4-carbonitrile; 2-Chloro-5-amino-4-cyanopyridine; 4-Cyano-2-chloro-5-aminopyridine; 5-Amino-2-chloro-4-cyanopyridine; 2-Chloro-5-aminoisonicotinonitrile; 5-Amino-2-chloro-4-pyridinecarbonitrile; 1359828-87-7; 5-Amino-2-chloropyridine-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Chloroisonicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.