Description

tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for new chemical entities (NCEs).
• Proteolysis Targeting Chimera (PROTAC) Development: Its structure makes it a potential component in the linker or ligand design for bifunctional degrader molecules.
• Contract Manufacturing (CMO/CDMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate
CAS No.	1359704-84-9
Molecular Formula	C13H21NO3
Molecular Weight	239.31 g/mol
Synonyms	6-Boc-2-oxo-6-azaspiro[3.5]nonane; 2-Oxo-6-azaspiro[3.5]nonane-6-carboxylic acid tert-butyl ester; tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate; 6-(tert-Butoxycarbonyl)-6-azaspiro[3.5]nonan-2-one; Boc-6-azaspiro[3.5]nonan-2-one; CAS 1359704-84-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for applications requiring the highest regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.