Description

5-Oxa-2-Azaspiro[3.4]Octane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is valued for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with complex three-dimensional architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its spirocyclic core.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional degraders.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for target identification and validation studies.
• Academic & Contract Research: Utilized in university and CRO settings for method development and exploratory synthesis projects.

Basic Information

Product Name	5-Oxa-2-Azaspiro[3.4]Octane Hydrochloride
CAS No.	1359656-11-3
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	2-Aza-5-oxaspiro[3.4]octane hydrochloride; 5-Oxa-2-azaspiro[3.4]octane, hydrochloride; 5-Oxa-2-azaspiro[3.4]octane HCl; Spiro[3.4]octane, 5-oxa-2-aza-, hydrochloride; 2-Azaspiro[3.4]octan-5-one, oxime, hydrochloride (related); Azaspirooctane hydrochloride derivative
EINECS	Contact for details

Quality Control

Our 5-Oxa-2-Azaspiro[3.4]Octane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.